DaTscan (Dopamine active Transporter scan), dopamine, dopaminergic neurons, ethanol, gamma camera, gamma photon energy, I-123, iodine, ioflupane (I-123), medical imaging, Parkinson disease, Parkinsonian syndrome, presynaptic dopamine transporters, radioactive isotope, radionuclide
Parkinson disease DaTscan (Dopamine active Transporter scan)
Test 3 of 4: 12 October 2016
*“DaTSCAN is a solution of ioflupane (123I) for injection into a living test subject.
The iodine introduced during manufacture is a radioactive isotope, I-123, and it is the properties of this isotope that makes the solution visible to a gamma camera. I-123 has a half life of approximately 13 hours and a gamma photon energy of 159 keV making it an appropriate radionuclide for medical imaging. The solution also contains 5% ethanol to aid solubility and is supplied sterile since it is intended for intravenous use.
Ioflupane has a high binding affinity for presynaptic dopamine transporters (DAT) in the brains of mammals, in particular the striatal region of the brain. A feature of Parkinson’s disease is a marked reduction in dopaminergic neurons in the striatal region. By introducing an agent that binds to the dopamine transporters a quantitative measure and spatial distribution of the transporters can be obtained.”: